A case of microgranular variant of acute promyelocytic leukemia with strong positive reaction in nonspecific esterase stain.
- Author:
Jeong N EOM
1
;
Woong Oo LEE
;
Think Ou KIM
;
Doh Sik MINN
Author Information
1. Department of Clinical Pathology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Microgranular variant;
Acute promyelocytic leukemia;
Nonspecific esterase
- MeSH:
Carboxylesterase*;
Cytogenetics;
Cytoplasm;
Female;
Fever;
Humans;
Immunophenotyping;
Intracranial Hemorrhages;
Leukemia, Promyelocytic, Acute*;
Leukocytes;
Leukocytosis;
Sodium;
Vomiting
- From:Korean Journal of Clinical Pathology
2000;20(5):455-458
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of microgranular variant of acute promyelocytic leukemia with strong positivity in nonspecific esterase stain (inhibited by sodium fluoride) in a 21-onth-ld girl who had complained of intermittent fever and severe vomiting. At admission, she showed marked leukocytosis in the peripheral blood. The majority of leukocytes were immature cells which exhibited marked nuclear irregularity and had sparse dust-ike granules in their cytoplasm. In immunophenotyping, these cells showed CD13 and CD33 positivity and in cytogenetic study, they showed t(15;17) abnormality. The patient died at the 6th hospital day because of pulmonary and intracranial hemorrhage.
