Thrombolysis by Recombinant Tissue-Type Plasminogen Activator in Patients with Acute Myocardial Infarction.
10.4070/kcj.1989.19.2.229
- Author:
Duk Kyung KIM
;
Jae Joong KIM
;
Cheol Ho KIM
;
Moon Hong DO
;
Sung Wook PARK
;
Dae Won SOHN
;
Kyu Hyung RYU
;
Byung Hee OH
;
Young Bae PARK
;
Yun Shik CHOI
;
Jung Don SEO
;
Young Woo LEE
- Publication Type:Original Article
- Keywords:
Acute myocardial infarction;
Thrombolysis;
Recombinant tissue-type Plasminogen Acivator(rt-PA)
- MeSH:
Angioplasty, Balloon, Coronary;
Arteries;
Coronary Angiography;
Coronary Vessels;
Creatine;
Creatine Kinase;
Ergonovine;
Fibrinolytic Agents;
Hemorrhage;
Humans;
Mortality;
Myocardial Infarction*;
Reperfusion;
Shock, Cardiogenic;
Spasm;
Tissue Plasminogen Activator*
- From:Korean Circulation Journal
1989;19(2):229-236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Myocardial infarction is usually associated with thrombotic occlusion of an artherosclerotic coronary artery. Reperfusion induced by administration of thrombolytic agents may presserve myocardial function and reduce mortality. At a mean of 272 minutes from symtom onset, 7 patients with acute myocardial infarction received recombinant tissue-type Plasminogen Activator. The results are as followings: 1) Reperfusion of the infarct-related artery was observed in all of the 5 patients in whom coronary angiography was performed 19 hour after initiation of drug infusion. Ergonovine challenge test, done in 1 patient who showed normal coronary artery, did not induced coronary spasm. 2) The maximal value of Creatine Kinase and Creatine Kinase-MB(2098+/-2107U/L and 728+/-532U/L, respectively) occured at 7.2+/-4.3 hour, respectively. A nadir value of fibrinogen(42+/-21% of the preinfusion value) occured at 3.1+/-2.0 hour. 3) Major bleeding episodes occured in 3 patients. Major cardiac events were angina followed by percutaneous transluminal coronary angioplasty in 1 patient; cardiogenic shock in 2 patients, one of whom also experienced recurrent ventricular tachycardia;reinfarction in 1 patient, 3 of the 7 patients died.
