Epstein-Barr Virus Brainstem Encephalitis With Anti-N-methyl-D-aspartate Receptor Antibodies.
- Author:
Jung Ah LIM
1
;
Jung Ick BYUN
;
Soon Tae LEE
;
Keun Hwa JUNG
;
Young Soo KIM
;
Jeong Min KIM
;
Sang Kun LEE
;
Kon CHU
Author Information
1. Department of Neurology, Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. stemcell.snu@gmail.com
- Publication Type:Case Report
- Keywords:
Encephalitis;
Epstein-Barr virus;
N-Methyl-D-aspartate
- MeSH:
Antibodies;
Autoantibodies;
Brain Stem;
Encephalitis;
Herpesvirus 4, Human;
Humans;
Immunotherapy;
N-Methylaspartate;
Neurologic Manifestations
- From:Journal of the Korean Neurological Association
2013;31(3):199-202
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The neurological manifestations caused by Epstein-Barr virus (EBV) occur only rarely in association with its primary infection or reactivation. The mechanism by which EBV produces neurological disease is unknown. This article describes two cases of polymerase-chain-reaction-proven EBV brainstem encephalitis. The sera of both patients contained autoantibodies against N-methyl-D-aspartate receptor (NMDAR), suggesting the presence of a secondary immunological mechanism. Prospective studies are needed to reveal whether the subgroup of patients with EBV encephalitis and anti-NMDAR antibodies have different clinical presentations and would benefit from immunotherapy.
