Glucose transporter 1 (GLUT1) expression is associated with intestinal type of gastric carcinoma.
10.3346/jkms.2000.15.4.420
- Author:
Wan Seop KIM
1
;
Young Youl KIM
;
Se Jin JANG
;
Kuchan KIMM
;
Myeong Ho JUNG
Author Information
1. Division of Cancer Research, National Institute of Health, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Monosaccharide Transport Proteins;
Stomach Neoplasms;
Prognosis
- MeSH:
Adenocarcinoma/pathology;
Adenocarcinoma/chemistry+ACo-;
Adult;
Aged;
Female;
Gastric Mucosa/pathology;
Gastric Mucosa/chemistry+ACo-;
Human;
Intestines;
Male;
Metaplasia;
Middle Age;
Monosaccharide Transport Proteins/analysis+ACo-;
Neoplasm Proteins/analysis+ACo-;
Reverse Transcriptase Polymerase Chain Reaction;
Stomach Neoplasms/pathology;
Stomach Neoplasms/chemistry+ACo-;
Tumor Markers, Biological/analysis+ACo-
- From:Journal of Korean Medical Science
2000;15(4):420-424
- CountryRepublic of Korea
- Language:English
-
Abstract:
Increased expression of glucose transporter1 (GLUT1) has been reported in many human cancers. We hypothesized that the degree of GLUT1 might provide a useful biological information in gastric adenocarcinoma. RT-PCR and immunostaining were used to analyze GLUT1 expression in gastric cancer. RT-PCR showed GLUT1 expression was not largely detected in normal gastric tissue but was detected in cancerous gastric tissue of counterpart. By immunohistochemistry, GLUT1 protein was absent in normal gastric epithelium and intestinal metaplasia. 11 of 65 patients with gastric adenocarcinoma had specific GLUT1 immunostaining in a plasma membrane pattern with varied intensities. GLUT1 protein did not show any significant correlation with tumor stage and nodal metastasis (p+AD4-0.05 by Mann-Whitney test). However, the positive immunostaining for GLUT1 is associated with intestinal differentiation (p+AD0-0.003). Our results suggest that GLUT1 protein is associated with intestinal type of gastric cancer.
