Concurrent chemotherapy and radiotherapy in invasive cervical cancer patients with high risk factors.
10.3346/jkms.2000.15.4.436
- Author:
Tchan Kyu PARK
1
;
Soo Nyung KIM
;
Sang Wun KIM
;
Gwi Eon KIM
;
Chang Ok SUH
Author Information
1. Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Comparative Study
- Keywords:
Concurrent Chemoradiation;
Cervix Neoplasms;
Risk Factors;
Radiation
- MeSH:
Adenocarcinoma/radiotherapy;
Adenocarcinoma/mortality;
Adenocarcinoma/drug therapy;
Adult;
Aged;
Antineoplastic Agents, Combined/therapeutic use+ACo-;
Antineoplastic Agents, Combined/adverse effects;
Carboplatin/administration +ACY- dosage;
Carcinoma, Squamous Cell/radiotherapy;
Carcinoma, Squamous Cell/mortality;
Carcinoma, Squamous Cell/drug therapy;
Cervix Neoplasms/radiotherapy+ACo-;
Cervix Neoplasms/mortality;
Cervix Neoplasms/drug therapy;
Chemotherapy, Adjuvant/adverse effects;
Cisplatin/administration +ACY- dosage;
Combined Modality Therapy;
Comparative Study;
Cyclophosphamide/administration +ACY- dosage;
Doxorubicin/administration +ACY- dosage;
Female;
Fluorouracil/administration +ACY- dosage;
Gastrointestinal Diseases/etiology;
Gastrointestinal Diseases/epidemiology;
Hematologic Diseases/etiology;
Hematologic Diseases/epidemiology;
Hepatitis, Toxic/etiology;
Hepatitis, Toxic/epidemiology;
Human;
Kidney Diseases/epidemiology;
Kidney Diseases/chemically induced;
Korea/epidemiology;
Life Tables;
Lymphatic Metastasis;
Middle Age;
Particle Accelerators;
Radiotherapy, High-Energy+ACo-/adverse effects;
Retrospective Studies;
Risk;
Survival Analysis;
Treatment Outcome
- From:Journal of Korean Medical Science
2000;15(4):436-441
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to evaluate the survival of 395 previously untreated cervical cancer patients with at least one high risk factor following concurrent chemoradiation and to assess the toxicities. Two different chemotherapy regimens were used for concurrent chemoradiation. In the patients with squamous cell carcinoma, 100 mg/m2 of cisplatin was infused intravenously, followed immediately by five consecutive daily administrations of 5-fluorouracil, 1,000 mg/m2/day, each infused intravenously over 24 hr. As for the patients with adenocarcinoma, 70 mg/m2 of cisplatin, 250 mg/m2 of cytoxan and 45 mg/m2 of adriamycin were administered intravenously on days 1, 2, and 3, respectively. The 5-year survival rate was 54.4+ACU- with stage III and IV, 62.6+ACU- with lymph node metastasis on computed tomogram or MRI, 77.9+ACU- with stage I-II disease with lesion size +AD4- or +AD0-4 cm, and 50.3+ACU- with small cell carcinoma or adenocarcinoma. Side effects from concurrent chemoradiation such as nausea, vomiting, and alopecia were present in all 395 cases. Anemia, leukopenia, thrombocytopenia, hepatotoxicity, and nephrotoxicity were observed to varying degrees, but there was no toxic death. This study suggests that cisplatin-based concurrent chemoradiation in treating cervical cancer patients with high risk factors is effective and relatively well tolerated, with acceptable toxicity.
