Association of the dopamine transporter gene with Parkinson's disease in Korean patients.
10.3346/jkms.2000.15.4.449
- Author:
Jae Woo KIM
1
;
Dae Hyun KIM
;
Sang Ho KIM
;
Jae Kwan CHA
Author Information
1. Department of Neurology, Dong-A University College of Medicine, Busan, Korea. jwkim+AEA-mail.donga.ac.kr
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Dopamine;
Minisatellite Repeats;
Variable Number Tandem Repeat;
Polymorphism(Genetics);
Parkinson Disease
- MeSH:
Aged;
Alleles;
Carrier Proteins/genetics+ACo-;
Case-Control Studies;
Comparative Study;
Female;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Human;
Korea/epidemiology;
Male;
Middle Age;
Minisatellite Repeats+ACo-;
Odds Ratio;
Parkinson Disease/genetics+ACo-;
Parkinson Disease/epidemiology
- From:Journal of Korean Medical Science
2000;15(4):449-451
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dopamine transporters (DAT) uptake neurotoxic substances such as 1-methyl-4-phenylpyridinium (MPP) in the dopaminergic nerve terminals and may confer susceptibility to cytotoxic effects of neurotoxic substance. The association of a variable number tandem repeat polymorphism in the DAT gene with Parkinson's disease (PD) in a Korean population was studied. The 10-copy allele was the most common, accounting for 77.2+ACU- and 81.6+ACU- of alleles in PD patients and control subjects, respectively. The rare 11-copy allele was more common in the patients (odds ratio +AD0- 2.5, 95+ACU- confidence interval +AD0- 1.1-5.7, p+ADw-0.02). It is suggested that the 11-copy allele of the DAT gene may confer susceptibility to PD for some patients in Korea.
