A Case of Rituximab Use in Rheumatoid Arthritis Following Anti-TNF-Associated Tuberculosis.
10.4078/jrd.2012.19.2.100
- Author:
Kyeong Hyun KIM
1
;
Ki Won MOON
;
Jeong Won HEO
;
Won Ho LEE
;
Sang Hoon LEE
;
Cheol Min JEONG
;
Hyun Sun PARK
Author Information
1. Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea. kiwonmoon@kangwon.ac.kr
- Publication Type:Case Report
- Keywords:
Rheumatoid arthritis;
TNF inhibitor;
Rituximab;
Tuberculosis
- MeSH:
Antibodies, Monoclonal, Humanized;
Antibodies, Monoclonal, Murine-Derived;
Arthritis;
Arthritis, Rheumatoid;
Cough;
Fever;
Humans;
Middle Aged;
Prednisolone;
Sputum;
Tuberculosis;
Tuberculosis, Pulmonary;
Tumor Necrosis Factor-alpha;
Weight Loss;
Adalimumab;
Rituximab
- From:Journal of Rheumatic Diseases
2012;19(2):100-103
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Rituximab has been shown to be effective in rheumatoid arthritis (RA) and is recommended for patients exhibiting an inadequate response to tumor necrosis factor (TNF) inhibitors. To date, there have been no reports of tuberculosis in RA patients treated with rituximab. We report the use of rituximab in a TNF inhibitor-refractory RA patient who had developed tuberculosis. A 52-year-old man with RA had been treated with adalimumab for 3 months, but failed to respond well to the treatment. He reported fever, coughing, sputum, and weight loss. He was diagnosed with pulmonary tuberculosis and started anti-tuberculosis medication. His arthritis was not controlled for despite increasing the dose of prednisolone. He was treated with rituximab without serious adverse effects. Sixteen weeks later, he demonstrated improvement with both arthritis and tuberculosis.
