Antiplaque and antigingivitis effects of a mouthrinse containing cetylpyridinium chloride, triclosan and dipotassium glycyrrhizinate.
10.5051/jpis.2012.42.2.33
- Author:
Jae Yong SHIM
1
;
Sung Bin YIM
;
Jin Hyung CHUNG
;
Ki Seok HONG
Author Information
1. Department of Periodontology, Dankook University School of Dentistry, Cheonan, Korea. periohong@gmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Cetylpyridinium;
Dental plaque index;
Glycyrrhizic acid;
Prevention mouthrinse;
Triclosan
- MeSH:
Cetylpyridinium;
Citrates;
Dental Plaque Index;
Dinucleoside Phosphates;
Drug Combinations;
Gingivitis;
Glycyrrhizic Acid;
Hemorrhage;
Humans;
Hydrogen Peroxide;
Periodontal Index;
Sulfates;
Triclosan;
Zinc Compounds
- From:Journal of Periodontal & Implant Science
2012;42(2):33-38
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The goal of this study was to evaluate the clinical anitplaque and antigingivitis effects of a mouthrinse containing cetylpyridinium chloride (CPC), triclosan and dipotassium glycyrrhizinate (DPZ) in patients with gingivitis and mild periodontitis. METHODS: Thirty-two subjects were randomized into 2 groups. The test group used a mouthrinse containing 0.05% CPC, 0.02% triclosan and 0.02% DPZ, while the control group used a placebo mouthrinse. At baseline, 2 weeks and 4 weeks, the papillary bleeding index (PBI), Turesky-Quigley-Hein plaque index (PI) and Loe-Silness gingival index (GI) were assessed. During the experimental period, the patients used the mouthrinse for 30 seconds, 4 to 5 times/day (10 mL/time) within 30 minutes after toothbrushing. RESULTS: No adverse effects appeared in either the experimental or the control group. Regarding PBI, PI and GI values, statistical significance was detected between values at baseline and 2 weeks for both groups (P<0.05). In the experimental group, statistically significantly lower values were detected at 4 weeks compared to at 2 weeks. However, in the control group, no statistically significant difference was detected between the values at 2 weeks and 4 weeks. Additionally, the mean value after 4 weeks for the control group was slightly higher than the mean value after 2 weeks for the control group. CONCLUSIONS: This study for 4 weeks demonstrated that mouthrinses containing CPC, triclosan and DPZ may contribute to the reduction of supragingival plaque and gingivitis.
