Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs.
10.5051/jpis.2012.42.2.50
- Author:
Jung Seok LEE
1
;
Weon Yeong PARK
;
Jae Kook CHA
;
Ui Won JUNG
;
Chang Sung KIM
;
Yong Keun LEE
;
Seong Ho CHOI
Author Information
1. Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea. shchoi726@yuhs.ac
- Publication Type:Original Article
- Keywords:
Bone substitutes;
Guided tissue regeneration;
Periodontal disease;
Tissue engineering;
Tissue scaffolds
- MeSH:
Animals;
Bicuspid;
Bone Substitutes;
Dogs;
Guided Tissue Regeneration;
Inflammation;
Osteogenesis;
Periodontal Diseases;
Polymers;
Porifera;
Powders;
Regeneration;
Tissue Engineering;
Tissue Scaffolds;
Transplants
- From:Journal of Periodontal & Implant Science
2012;42(2):50-58
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. METHODS: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4x4x5 mm (buccolingual widthxmesiodistal widthxdepth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. RESULTS: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. CONCLUSIONS: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
