Short Term Effects of Topical Cyclosporine and Viscoelastic on the Ocular Surfaces in Patients with Dry Eye.
10.3341/kjo.2007.21.4.189
- Author:
Jun Woong MOON
1
;
Hyun Joo LEE
;
Ki Chul SHIN
;
Won Ryang WEE
;
Jin Hak LEE
;
Mee Kum KIM
Author Information
1. Department of Ophthalmology, Konkuk University Hospital, Seoul, Korea.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Dry eye;
Topical cyclosporine;
Topical viscoelastic
- MeSH:
Adjuvants, Immunologic/administration & dosage;
Administration, Topical;
Cell Count;
Chondroitin Sulfates/*administration & dosage;
Conjunctiva/drug effects/pathology;
Cyclosporine/*administration & dosage;
Drug Administration Schedule;
Drug Combinations;
Drug Therapy, Combination;
Dry Eye Syndromes/*drug therapy/metabolism/pathology;
Epithelium/drug effects/pathology;
Female;
Follow-Up Studies;
Goblet Cells/drug effects/pathology;
Humans;
Hyaluronic Acid/*administration & dosage;
Immunosuppressive Agents/*administration & dosage;
Male;
Middle Aged;
Ophthalmic Solutions/administration & dosage;
Tears/drug effects/metabolism;
Time Factors;
Treatment Outcome
- From:Korean Journal of Ophthalmology
2007;21(4):189-194
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces. METHODS: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer's test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer's test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA). RESULTS: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting (p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033). CONCLUSIONS: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.
