Neonatal Lupus Erythematosus in an Infant Born to an Asymptomatic Mother with Anti-SSA/SSB Antibodies.
- Author:
Ho Yeol LEE
1
;
Cheong Ha WOO
;
Hai Jin PARK
Author Information
1. Department of Dermatology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea. stratum@medigate.net
- Publication Type:Case Report
- Keywords:
Neonatal lupus erythematosus;
Subacute cutaneous lupus erythematosus
- MeSH:
Antibodies*;
Antibodies, Antinuclear;
Autoantibodies;
Autoimmune Diseases;
Biopsy;
Dermis;
Edema;
Epidermis;
Female;
Heart Block;
Humans;
Infant*;
Infant, Newborn;
Liver;
Lupus Erythematosus, Cutaneous;
Mothers*;
Serologic Tests;
Skin;
Telangiectasis
- From:Korean Journal of Dermatology
2016;54(6):481-484
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neonatal lupus erythematosus (NLE) is a rare autoimmune disease that has a clinical spectrum of cutaneous, cardiac, and systemic abnormalities in neonates. It is caused by transplacental passage of maternal anti-Ro and/or anti-La autoantibodies, which result in skin lesions such as subacute cutaneous lupus erythematosus, congenital heart block, and liver function and hematologic abnormalities. We report a case of NLE in a 31-day-old female infant who was born to a clinically asymptomatic mother with anti-SSA/Ro and anti-SSB/La antibodies. The baby presented with multiple erythematous patches and annular plaques on the face and trunk. The skin biopsy showed slight follicular plugging, focal hydropic degeneration of the basal epidermis and mild edema, telangiectasia, and perivascular and interstitial lymphohistiocytic infiltration in the upper dermis. Her serological tests were positive for antinuclear antibody (ANA), anti-SSA/Ro, and anti-SSB/La. These findings are consistent with NLE. The mother also had a positive autoantibody profile for ANA, anti-SSA/Ro, and anti-SSB/La without clinical symptoms.
