Asthmatics Without Rhinitis Have More Fixed Airway Obstruction Than Those With Concurrent Rhinitis.
10.4168/aair.2010.2.2.108
- Author:
An Soo JANG
1
;
Jong Sook PARK
;
June Hyuk LEE
;
Sung Woo PARK
;
Do Jin KIM
;
Soo Taek UH
;
Young Hoon KIM
;
Choon Sik PARK
Author Information
1. Asthma and Allergy Research Group, Division of Allergy and Respiratory Diseases, Soonchunhyang University, Bucheon Hospital, Bucheon, Korea. mdcspark@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Asthma;
allergic rhinitis;
airway obstruction
- MeSH:
Airway Obstruction;
Aspirin;
Asthma;
Body Mass Index;
Emphysema;
Eosinophils;
Humans;
Immunoglobulin E;
Prevalence;
Rhinitis;
Rhinitis, Allergic, Perennial;
Smoke;
Sputum
- From:Allergy, Asthma & Immunology Research
2010;2(2):108-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Rhinitis and asthma usually occur together. There are increasing evidences that allergic rhinitis (AR) may influence the clinical course of asthma. The aim of this study is to evaluate clinical parameters and therapeutic response in patients with between asthma and asthma with AR. METHODS: Four-hundred eighty-five patients with asthma and 428 asthmatics with AR, who had lesser than 50 years old and smoked less than 10 pack-years were recruited. We compared FEV1 and FEV1/FVC following bronchodilator, atopy, IgE, emphysema on HRCT, and aspirin intolerance between two groups. Also we compared physiologic fixed airway obstruction defined using FEV1/FVC and FEV1 less than 75% following anti-asthmatic drug for 1 year. RESULTS: 46.8% (428/913) asthmatics suffered from AR. There were no differences of total IgE, body mass index, PC20, sputum eosinophils and emphysema on HRCT between two groups. The age in asthmatics was higher than that in those with AR. FEV1/FVC was lower in asthmatics than in those with AR. The prevalence of atopy was higher in asthmatics with AR than in asthmatics. Aspirin intolerance was higher in asthmatics with AR than in asthmatics (42/218 vs 13/109, P=0.001). Fixed airway obstruction were more observed in asthmatics than in those with AR (39/319 vs 28/355, P=0.001) after anti-asthmatic drug for 1 year. CONCLUSIONS: Asthmatics with AR had more atopy and aspirin intolerance than asthmatics, and asthmatics had poor response to anti-inflammatory drugs than those with concurrent rhinitis, indicating that asthmatics have more fixed airway obstruction than those with concurrent rhinitis.
