Efficacy of Two Triple Eradication Regimens in Children with Helicobacter pylori Infection.
10.3346/jkms.2006.21.6.1037
- Author:
Jungi CHOI
1
;
Joo Young JANG
;
Joon Sung KIM
;
Hwa Young PARK
;
Yon Ho CHOE
;
Kyung Mo KIM
Author Information
1. Department of Pediatrics, Asan Medical Center, University of Ulsan, 388-1 Pungnap-dong, Songpa-gu, Seoul, Korea. kmkim@amc.seoul.kr
- Publication Type:Original Article ; Evaluation Studies ; Research Support, Non-U.S. Gov't
- Keywords:
Helicobacter pylori, Treatment Outcome, Child;
bismuth subsalicylate;
Amoxicillin;
Metronidazole
- MeSH:
Treatment Outcome;
Salicylates/*administration & dosage;
Retrospective Studies;
Organometallic Compounds/*administration & dosage;
Omeprazole/*administration & dosage;
Metronidazole/*administration & dosage;
Male;
Humans;
Helicobacter pylori/*drug effects;
Helicobacter Infections/*drug therapy;
Female;
Drug Combinations;
Clarithromycin/*administration & dosage;
Child, Preschool;
Child;
Bismuth/*administration & dosage;
Anti-Bacterial Agents/administration & dosage;
Amoxicillin/*administration & dosage;
Adolescent
- From:Journal of Korean Medical Science
2006;21(6):1037-1040
- CountryRepublic of Korea
- Language:English
-
Abstract:
Triple therapy with bismuth subsalicylate, amoxicillin, metronidazole (BAM) or with omeprazole, amoxicillin, clarithromycin (OAC) has been commonly used for the eradication of Helicobacter pylori infection. We compared the efficacy of these triple therapies in children with H. pylori infection. We retrospectively analyzed results in 233 children with H. pylori infection and treated with OAC (n=141) or BAM (n=92). Overall eradication rates of triple therapy with OAC and BAM were 74% and 85%, respectively, which showed no statistical difference. Our study showed that the triple therapy with BAM was more effective for the first-line eradication of H. pylori infection in Korean children, but has no statistical difference with OAC regimen.
