Association of Interleukin-10 A-592C Polymorphism in Taiwanese Children with Kawasaki Disease.
10.3346/jkms.2009.24.3.438
- Author:
Kai Chung HSUEH
1
;
Ying Ju LIN
;
Jeng Sheng CHANG
;
Lei WAN
;
Yu Hsin TSAI
;
Chang Hai TSAI
;
Chih Ping CHEN
;
Fuu Jen TSAI
Author Information
1. Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Mucocutaneous Lymph Node Syndrome;
Polymorphism;
Interleukin-10
- MeSH:
Alleles;
Asian Continental Ancestry Group/*genetics;
Child;
Child, Preschool;
Female;
Gene Frequency;
Genotype;
Humans;
Infant;
Interleukin-10/blood/*genetics;
Male;
Mucocutaneous Lymph Node Syndrome/diagnosis/*genetics;
Polymorphism, Genetic;
Promoter Regions, Genetic;
Taiwan
- From:Journal of Korean Medical Science
2009;24(3):438-442
- CountryRepublic of Korea
- Language:English
-
Abstract:
Elevated serum levels of interleukin-10 (IL-10) have been reported in patients with Kawasaki disease (KD). IL-10 reduces the inflammatory actions of macrophages and T cells and it may play a significant role in the regulation of inflammatory vascular damage associated with systemic vasculitis. The aim of this study was to examine whether -592 IL-10 promoter polymorphism is a susceptibility or severity marker of KD in Chinese patients in Taiwan. The study included 105 KD patients and 100 normal controls. Genotype and allelic frequencies for the IL-10 gene polymorphism in both groups were compared. There were no significant between-group differences in the genotype distribution of IL-10 A-592C gene polymorphism (P=0.08). However, the frequency of the -592*A allele was significantly increased in the patients with KD compared with controls (71.9% vs. 61.0%, P=0.019). The odds ratio for developing KD in individuals with IL-10-592*A allele was 1.64 (95% confidence interval, 1.06-2.52) compared to individuals with the IL-10-592*C allele. No significant difference was observed in the genotype and allelic frequencies for the IL-10 A-592C polymorphism between patients with and without coronary artery lesions. The IL-10-592*A allele may be involved in the development of KD in Taiwanese children.
