Non-association Between Polymorphisms of the Frizzled Receptor Genes and Bone Mineral Density in Postmenopausal Korean Women.
10.3346/jkms.2009.24.3.443
- Author:
Jung Gu KIM
1
;
Hoon KIM
;
Byung Chul JEE
;
Chang Suk SUH
;
Young Min CHOI
;
Shin Yong MOON
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.kimjg@plaza.snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Bone Density;
Frizzled Receptors;
Polymorphism, Genetic;
Osteoprotegerin;
Biological Markers
- MeSH:
Alleles;
Asian Continental Ancestry Group/*genetics;
Child;
Child, Preschool;
Female;
Gene Frequency;
Genotype;
Humans;
Infant;
Interleukin-10/blood/*genetics;
Male;
Mucocutaneous Lymph Node Syndrome/diagnosis/*genetics;
Polymorphism, Genetic;
Promoter Regions, Genetic;
Taiwan
- From:Journal of Korean Medical Science
2009;24(3):443-447
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the association between single nucleotide polymorphisms (SNPs) in the frizzled (FZD) genes in the Wnt signal pathway and circulating osteoprotegerin (OPG), soluble receptor activator of NF-kappaB ligand (sRANKL) levels, bone turnover markers, and bone mineral density (BMD) in postmenopausal women. The SNPs in the FZD1, FZD5, FZD6, FZD7, and FZD9 genes were analyzed by direct sequencing in 371 postmenopausal Korean women. Levels of serum OPG, sRANKL, osteocalcin, C-telopeptide of type I collagen, calcium, parathyroid hormone and calcitonin, and BMD at the lumbar spine and femoral neck were measured. The SNPs in the FZD1, FZD5, FZD7, and FZD9 genes, and in exon 2 of the FZD6 gene were not observed. No significant differences in the adjusted BMD of lumbar spine and femoral neck and serum levels of OPG, sRANKL, and bone markers were noted among the single or haplotype genotypes of the L345M and E664A SNPs in the FZD6 gene and the distributions of these single or haplotype genotypes were not different according to the bone mass status. In conclusion, the polymorphisms of the FZD genes are not associated with BMD of the lumbar spine and femoral neck, bone turnover markers, or circulating OPG-sRANKL in Korean women.
