Neuroblastoma Originating from Extra-abdominal Sites: Association with Favorable Clinical and Biological Features.
10.3346/jkms.2009.24.3.461
- Author:
Ki Woong SUNG
1
;
Keon Hee YOO
;
Hong Hoe KOO
;
Ju Youn KIM
;
Eun Joo CHO
;
Yeon Lim SEO
;
Jhingook KIM
;
Suk Koo LEE
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Neuroblastoma;
Prognosis;
Thorax;
Transplantation, Autologous
- MeSH:
Disease-Free Survival;
Female;
Ferritins/blood;
Humans;
L-Lactate Dehydrogenase/blood;
Male;
Neuroblastoma/*diagnosis/therapy;
Phosphopyruvate Hydratase/blood;
Prognosis;
Treatment Outcome;
Vanilmandelic Acid/urine
- From:Journal of Korean Medical Science
2009;24(3):461-467
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neuroblastomas originating from different sites might have different clinical and biological characteristics. In the present study, the clinical (age, sex and stage) and biological (N-myc amplification, Shimada pathology and levels of lactate dehydrogenase, ferritin and neuron-specific enolase) characteristics of patients with newly diagnosed neuroblastoma were compared according to the site of tumor origin (extra-abdominal versus abdominal). The event-free survival rate (EFS) was also compared between the two groups. Among 143 neuroblastomas, 115 tumors originated from the abdomen, 26 from extra-abdominal sites and 2 from unknown primary sites. Frequencies of stage 4 tumor and N-myc amplified tumor were lower in the extra-abdominal group than in the abdominal group (34.6% vs. 60.0%, P=0.019 and 4.2% vs. 45.0%, P<0.001, respectively). Levels of lactate dehydrogenase, ferritin and neuron-specific enolase were significantly lower in the extra-abdominal group than in the abdominal group. The probability of 5-yr EFS (+/-95% confidence interval) was higher in the extra-abdominal group than in the abdominal group (94.4+/-10.6% vs. 69.4+/-9.4%, P=0.026). Taken together, neuroblastomas originating from extra-abdominal sites might be associated with more favorable clinical and biological characteristics and a better outcome than neuroblastomas originating from abdomen.
