Association between Painful Physical Symptoms and Clinical Outcomes in Korean Patients with Major Depressive Disorder: A Three-Month Observational Study.
- Author:
Min Soo LEE
1
;
Sun Young YUM
;
Jin Pyo HONG
;
Se Chang YOON
;
Jai Sung NOH
;
Kwang Hun LEE
;
Jung Ki KIM
;
Sang Yeol LEE
;
Pritibha SINGH
;
Tamas TREUER
;
Victoria REED
;
Joel RASKIN
Author Information
1. Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Pain;
Depressive disorder;
Major;
Korea;
Quality of life;
Depression;
Culture
- MeSH:
Asian Continental Ancestry Group;
Depression;
Depressive Disorder;
Depressive Disorder, Major;
Female;
Humans;
Korea;
Quality of Life
- From:Psychiatry Investigation
2009;6(4):255-263
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This paper aims to examine the association between painful physical symptoms (PPS) and major depressive disorder (MDD) in a naturalistic clinical practice setting within a Korean population. METHODS: Patients with acute MDD that joined a multicountry, observational, three-month study in six Asian countries and regions were classified as PPS+ (mean score > or =2) and PPS- (mean score <2) using the modified Somatic Symptom Inventory. In this analysis, we report the results from the Korean subset, where depression severity was assessed using the Clinical Global Impression of Severity (CGI-S) scale and 17-item Hamilton Depression Rating Scale (HAMD(17)). Pain severity was measured using a visual analogue scale (VAS), while the EuroQoL (EQ-5D) assessed patient well-being. RESULTS: Of 198 patients, 45.96% (91/198) of patients were classified as PPS+, of which 78.02% (71/91) were women. PPS+ patients had significantly more severe depression at baseline {CGI-S score, mean [standard deviation (SD)], PPS+: 5.09 [0.79]; PPS-: 4.63 [0.76]; p<0.001; HAMD(17) total score, mean [SD], PPS+: 24.34 [5.24]; PPS-: 20.76 [5.12]; p<0.001} and poorer quality of life [EQ-5D overall health state, mean (SD), PPS+: 39.37 (20.52); PPS-: 51.27 [20.78]; p<0.001] than PPS- patients. Both groups improved significantly (p<0.001) in depression and pain severity outcomes, as well as quality of life by endpoint, but no significant within-group baseline-to-endpoint change wase observed. CONCLUSION: The frequency of PPS was common in Korean patients with MDD, and was associated with more severe depression, poorer quality of life, and a trend towards poorer clinical outcome.
