Resolution of Pregabalin and Mirtazapine Associated Restless Legs Syndrome by Bupropion in a Patient with Major Depressive Disorder.
- Author:
Young Min PARK
1
;
Heon Jeong LEE
;
Seung Gul KANG
;
Jae Hyuck CHO
;
Leen KIM
Author Information
1. Department of Neuropsychiatry, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea. medipark@hanmail.net
- Publication Type:Case Report
- Keywords:
Restless legs syndrome;
Bupropion;
Pregabalin;
Mirtazapine
- MeSH:
Bupropion;
Depressive Disorder, Major;
Dopamine;
gamma-Aminobutyric Acid;
Humans;
Mianserin;
Norepinephrine;
Nucleus Accumbens;
Prefrontal Cortex;
Restless Legs Syndrome;
Serotonin Uptake Inhibitors;
Synaptic Transmission;
Pregabalin
- From:Psychiatry Investigation
2009;6(4):313-315
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bupropion is a selective norepinephrine and dopamine reuptake inhibitor with no serotonergic activity, and is therefore an antidepressant with unique pharmacological properties. There are some reports that selective serotonin reuptake inhibitors (SSRIs) or mirtazapine can induce adverse effects including restless legs syndrome (RLS) and that bupropion can reverse these adverse effects. Here, we report about a patient with a major depressive disorder who exhibited RLS after being treated with pregabalin and mirtazapine. This adverse effect disappeared after having switched from mirtazapine to bupropion. Bupropion inhibits the reuptake of dopamine and increases dopamine neurotransmission in both the nucleus accumbens and the prefrontal cortex. This pharmacological profile can be effective in patients with RLS related to dopamine hypoactivity. However, the limitations of this single case report mean that further investigations with larger samples are needed.
