A Case of Tonic Spasm Presenting as Sole Manifestation of Multiple Sclerosis.
- Author:
Bo Ram LEE
1
;
Harry NA
;
San JEONG
;
Kyung Ho YU
;
Hyeo Il MA
;
Byung Chul LEE
Author Information
1. Department of Neurology, Hallym University College of Medicine.
- Publication Type:Case Report
- Keywords:
Multiple sclerosis;
Spasm;
Ephaptic transmission
- MeSH:
Axons;
Carbamazepine;
Consciousness;
Demyelinating Diseases;
Extremities;
Female;
Humans;
Lymphokines;
Magnetic Resonance Imaging;
Multiple Sclerosis*;
Pyramidal Tracts;
Spasm*;
Tegmentum Mesencephali
- From:Journal of the Korean Neurological Association
2001;19(2):167-169
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A young woman developed a hemilateral tonic spasm associated with multiple sclerosis. Her symptoms included brief recurrent episodes of abnormal, often painful, posturing of one or more extremities without alteration of consciousness. An area of demyelination in the contralateral cerebral peduncle was observed on a magnetic resonance imaging. The tonic attacks abated with carbamazepine therapy. The pathophysiology may involve ephaptic transmission between demyelinated fibers in acute plaques within the corticospinal tract secondary to axonal irritation by lymphokines. (J Korean Neurol Assoc 19(2):167~169, 2001)
