Prognostic Significance of the Decreased Rate of Perioperative Serum Carcinoembryonic Antigen Level in the Patients With Colon Cancer After a Curative Resection.
- Author:
Tae Doo JUNG
1
;
Jong Han YOO
;
Min Jae LEE
;
Ha Kyung PARK
;
Jae Ho SHIN
;
Min Sung AN
;
Tae Kwun HA
;
Kwang Hee KIM
;
Ki Beom BAE
;
Tae Hyeon KIM
;
Chang Soo CHOI
;
Min Kyung OH
;
Kwan Hee HONG
Author Information
- Publication Type:Original Article
- Keywords: Colon neoplasms; Carcinoembryonic antigen; Prognostic factor
- MeSH: Carcinoembryonic Antigen; Colon; Colonic Neoplasms; Disease-Free Survival; Follow-Up Studies; Humans; Multivariate Analysis; Prognosis; Retrospective Studies
- From:Annals of Coloproctology 2013;29(3):115-122
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The serum level of carcinoembryonic antigen (CEA) is a clinical prognostic factor in the follow-up evaluation of patients with colon cancer. We aimed to evaluate the prognostic significance of the rate of decrease of the perioperative serum CEA level in patients with colon cancer after a curative resection. METHODS: A total of 605 patients who underwent a curative resection for colon cancer between January 2000 and December 2007 were enrolled retrospectively. The rate of decrease was calculated using the following equation: ([preoperative CEA - postoperative CEA]/[preoperative CEA] x100). RESULTS: In the group with a preoperative serum CEA level of >5 ng/mL, the normalized group with a postoperative serum CEA level of < or =5 ng/mL showed a better overall survival (OS) rate and disease-free survival (DFS) rate than those of the non-normalized group (P < or = 0.0001). The "cutoff values" of the rate of decrease in the perioperative serum CEA that determined the OS and the DFS were 48.9% and 50.8%, respectively. In the multivariate analysis of preoperative serum CEA levels >5 ng/mL, the prognostic factors for the OS and the DFS were the cutoff value (P < 0.0001) and the pN stage (P < 0.0001). CONCLUSION: A rate of decrease of more than 50% in the perioperative serum CEA level, as well as the normalization of the postoperative serum CEA level, may be useful factors for determining a prognosis for colon cancer patients with high preoperative CEA levels.
