The Role of Superantigen in Nasal Polypogenesis.
- Author:
Byung Ki YOON
1
;
Dae Woo KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. kicubi@daum.net
- Publication Type:Review
- Keywords:
Chronic Rhinosinusitis;
Nasal Polyps;
Staphylococcus aureus exotoxins;
Superantigens
- MeSH:
Antigen Presentation;
Eosinophilia;
Exotoxins;
Immunoglobulin E;
Lymphocytes;
Nasal Polyps;
Phenotype;
Staphylococcus aureus;
Superantigens
- From:Journal of Rhinology
2013;20(2):88-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Superantigens are potent immunostimulatory exotoxins well known to be produced by Staphylococcus aureus (S. aureus). These exotoxins have capacity to act as superantigens by binding with the variable beta(Vbeta) region of lymphocytes in chronic rhinosinusitis with nasal polyposis, bypassing normal antigen processing and directly stimulating a massive inflammatory response. Accumulated evidence is now convincing that S. aureus superantigens may play an important role in development of chronic rhinosinusitis with nasal polyposis which are thought to skew the cytokine response towards a Th2 phenotype inducing eosinophilia and the production of polycolonal IgE. This review summarizes the current evidence of characteristics and its role superantigens in pathophysiology of nasal polyposis.
