An Autopsy Confirmed Case of Behavioral Variant Frontotemporal Dementia with Corticobasal Degeneration Pathology.

Author: Eun Joo KIM ¹ ; Seung Ha PARK ; Jeong Hee LEE ; Jae Hyeok LEE ; Young Min LEE ; Seong Jang KIM ; Jin Hong SHIN ; Myung Jun SHIN ; Myung Jun LEE ; Jae Woo AHN ; Suk SUNG ; Do Youn PARK ; Dae Soo JUNG ; William W SEELEY ; Gi Yeong HUH
Author Information

1. Department of Neurology, Pusan National University School of Medicine, Yangsan, Korea.
Publication Type:Case Report
Keywords: Behavioral variant frontotemporal dementia; Autopsy; Corticobasal degeneration
MeSH: Autopsy*; Cerebral Cortex; Coiled Bodies; Frontotemporal Dementia*; Humans; Inclusion Bodies; Middle Aged; Neurons; Pathology*
From:Journal of the Korean Neurological Association 2015;33(3):178-182
CountryRepublic of Korea
Language:Korean
Abstract: A 63-year-old man presented with a 1.5-year history of progressive personality changes. Clinical evaluations revealed severe frontal dysfunction and bilateral frontal atrophy/glucose hypometabolism. He was diagnosed as probable behavioral variant frontotemporal dementia. He continued to decline, and died at the age of 66. At autopsy, numerous tau-positive gilial threads and coiled bodies were observed in the white matter. Tau-positive astrocytic plaques and neuronal cytoplasmic inclusions were also seen in cerebral cortices, which were compatible with corticobasal degeneration.