Identification of Lymph Node Micrometastases in Dukes' B Colorectal Cancer Patients Using Monoclonal Antibodies against Cytokeratin-19.
- Author:
Eung Jin SHIN
1
;
Hyung Chul KIM
;
Chul Wan LIM
;
Gyu Seok CHO
;
Chong Woo CHU
;
Moo Joon BAEK
;
Nae Gyung PARK
;
Yong Seok JANG
;
Jae Joon KIM
;
Ok Pyung SONG
;
Min Hyuk LEE
Author Information
1. Department of Surgery, Soon Chun Hyang University Hospital, Bucheon, Korea.
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
Lymph node;
Micrometastases;
Cytokeratin-19;
CEA
- MeSH:
Antibodies, Monoclonal*;
Colorectal Neoplasms*;
Follow-Up Studies;
Humans;
Keratin-19*;
Lymph Nodes*;
Neoplasm Micrometastasis*;
Recurrence;
Retrospective Studies
- From:Journal of the Korean Surgical Society
2004;66(5):385-390
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aims of this study were to immunohistochemically identify lymph node micormetastases in Dukes' B colorectal cancer patients, and determine the relationship between lymph node micrometastases and other prognostic factors and recurrence rates. METHODS: A retrospective analysis was conducted of 990 lymph nodes from Dukes' B 42 patients who had undergone radical colorectal resection. These lymph nodes were immunohistochemically examined with monoclonal antibodies against cytokeratin-19. The prognostic factors and recurrent rates were compared between patients with and without lymph node micrometastases. RESULTS: Micrometastases were confirmed in 19 nodes (1.9%) from 9 patients (21.4%). No correlations were observed between micrometastases and the prognostic factors, with the exception of the preoperative CEA level. 8 of the 9 (88.9%) patients with micrometastases had preoperative CEA levels significantly elevated above 5 ng/ml (P<0.0001). There were no significant differences in the recurrent rates (P=0.0572) between patients with and without micrometastases during the short term follow up period (14.8 months) at the 95% confidence interval, but there were significant differences at the 90% confidence interval. CONCLUSION: High preoperative CEA levels increase the risk for micrometastases, and the presence of micrometastases might increase the possibility of recurrence. Thus, a routine immunohistochemical technique for identifying micrometastases is recommended in the patients with a high preoperative CEA level. However, a more definite clinical significance of lymph node micrometastases awaits further extensive prospective studies.
