Does blastomere biopsy in preimplantation genetic diagnosis affect early serum beta-hCG levels?.
10.5653/cerm.2011.38.1.31
- Author:
Yeon Jean CHO
1
;
Jin Yeong KIM
;
In Ok SONG
;
Hyung Song LEE
;
Chun Kyu LIM
;
Mi Kyoung KOONG
;
Inn Soo KANG
Author Information
1. Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. ikang67@kwandong.ac.kr
- Publication Type:Original Article
- Keywords:
Preimplantation Genetic Diagnosis;
Human Chorionic Gonadotropin;
Blastomeres;
Biopsy;
Pregnancy Outcome;
Human
- MeSH:
Biopsy;
Blastomeres;
Chorionic Gonadotropin;
Female;
Humans;
Pregnancy;
Pregnancy Outcome;
Preimplantation Diagnosis;
Prostaglandins D;
Sperm Injections, Intracytoplasmic;
Trophoblasts
- From:Clinical and Experimental Reproductive Medicine
2011;38(1):31-36
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To determine whether the serum beta-human chorionic gonadotropin (hCG) profile following preimplantation genetic diagnosis (PGD) is lower than that of intracytoplasmic sperm injection (ICSI) cycles. METHODS: A total of 129 PGD cycles and 1,161 age-matched ICSI cycles, which resulted in pregnancy (serum beta-hCG> or =5 mIU/mL) on post-ovulation day (POD) 12 were included. We compared the mean serum beta-hCG levels on POD 12, 14, 21, and 28, doubling time of serum hCG, and created a cut-off value for predicting a singleton pregnancy in each group. RESULTS: The mean serum beta-hCG concentration of the PGD group was significantly lower than that of the control group on POD 12, 14, and 21. The doubling time of serum beta-hCG at each time interval showed no significant difference. The cut-off-value of serum beta-hCG for predicting a single viable pregnancy was 32.5 mIU/mL on POD 12 and 113.5 mIU/mL on POD 14 for the PGD group, which was lower than that for the control group. CONCLUSION: Blastomere biopsy may decrease the beta-hCG-producing activity of the trophoblasts, especially in early pregnancy. Setting a lower cut-off value of serum beta-hCG for predicting pregnancy outcomes in PGD may be needed.
