Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome.
10.5653/cerm.2011.38.1.42
- Author:
Joon Cheol PARK
1
;
Su Yeon LIM
;
Tae Kyu JANG
;
Jin Gon BAE
;
Jong In KIM
;
Jeong Ho RHEE
Author Information
1. Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu, Korea. r1670416@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Endometrial Hyperplasia;
Endometrium;
Biopsy;
Polycystic Ovary Syndrome;
Human
- MeSH:
Biopsy;
Body Mass Index;
Endometrial Hyperplasia;
Endometrial Neoplasms;
Endometrium;
Estradiol;
Fasting;
Female;
Glucose;
Humans;
Hyperplasia;
Incidence;
Insulin;
Insulin Resistance;
Polycystic Ovary Syndrome;
ROC Curve;
Sensitivity and Specificity;
Testosterone;
Uterine Diseases
- From:Clinical and Experimental Reproductive Medicine
2011;38(1):42-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS). METHODS: We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2 hours postprandial glucose and insulin, insulin resistance, body mass index, endometrial thickness, menstrual status from 117 women with PCOS. Statistical analysis was performed with chi square and t-test, p-value<0.05 was considered as statistically significant. And receiver operating characteristic curve was used to find predictable clinical factors for endometrial disease and to decide the cuff off values. RESULTS: In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76.9%), endometrial hyperplasia in 25 women (21.4%), and endometrial cancer in 2 women (1.7%). Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex hyperplasia with atypia were diagnosed in 15 (12.8%), 6 (5.1%), 4 (3.4%) women, respectively. Age and endometrial thickness were significantly related with endometrial disease, p=0.013 and p=0.001, respectively. At the cut off level of 25.5 years in age, sensitivity and specificity predicting for endometrial disease were 70.4% and 55.6%, respectively (p=0.023). At the cut off level of 8.5 mm in endometrial thickness, sensitivity and specificity were 77.8% and 56.7%, respectively (p=0.000). CONCLUSION: In women with PCOS, the incidence of endometrial hyperplasia and cancer were 21.4% and 1.7%. The age and endometrial thickness may be used as clinical determining factors for endometrial biopsy.
