Comparison of elective single cleavage-embryo transfer to elective single blastocyst-embryo transfer in human IVF-ET.
10.5653/cerm.2011.38.1.53
- Author:
Sang Min KANG
1
;
Sang Won LEE
;
Hak Jun JEONG
;
San Hyun YOON
;
Jin Ho LIM
;
Seong Goo LEE
Author Information
1. Daegu Maria Fertility Clinic, Daegu, Korea. koo9406@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Single Embryo Transfer;
Twins;
Pregnancy;
Human
- MeSH:
Embryonic Structures;
Female;
Humans;
Live Birth;
Oocytes;
Pregnancy;
Pregnancy Rate;
Pregnancy, Twin;
Retrospective Studies;
Single Embryo Transfer;
Twins
- From:Clinical and Experimental Reproductive Medicine
2011;38(1):53-60
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study was carried out to compare the clinical outcome of elective single cleavage-embryo transfer (eSCET) to that of elective single blastocyst-embryo transfer (eSBET) in human IVF-ET. METHODS: This study was a retrospective study which analyzed for 614 women who visited the Daegu Maria Clinic from August 2008 to December 2009. All were under 37 years old and had more than 8 mm of endometrial thickness on the day of hCG administration and at least one good quality embryo on day 3. The eSCETs were performed on day 3 (n=450) and the eSBETs were conducted on day 5 (n=164). RESULTS: The numbers of retrieved oocytes, fertilized oocytes, and day 3 good quality embryos were significantly lower in the eSCET group (12.1+/-6.0, 8.2+/-4.6, and 4.2+/-3.1, respectively) compared to the eSBET group (16.7+/-7.2, 12.1+/-5.0, and 8.5+/-4.5, respectively; p<0.001). However, the clinical pregnancy, implantation, on-going pregnancy, and live birth rates of the eSCET group (46.7, 46.9, 40.0, and 36.7%, respectively) were not statistically different from those of the eSBET group (51.2, 51.8, 45.1, and 43.9%, respectively; p=0.318, 0.278, 0.254, and 0.103, respectively). CONCLUSION: These results suggested that elective single embryo transfer should be performed regardless of the developmental stage to women less than 37 years old who had more than 8 mm of endometrial thickness on the hCG administration day and at least one good quality embryo on day 3 in order to reduce the twin pregnancy rate without reducing the whole pregnancy rate.
