Prognostic Value of Body Mass Index in Korean Patients with Castration-Resistant Prostate Cancer.
10.4111/kju.2012.53.11.761
- Author:
Jeong Min PARK
1
;
Jung Soo NAM
;
Woong NA
;
Jong Jin OH
;
Sangchul LEE
;
Sung Kyu HONG
;
Seok Soo BYUN
;
Sang Eun LEE
Author Information
1. Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cancer specific survival;
Castration-resistant prostate cancer;
Obesity
- MeSH:
Alkaline Phosphatase;
Body Mass Index;
Follow-Up Studies;
Hemoglobins;
Humans;
Multivariate Analysis;
Neoplasm Grading;
Neoplasm Metastasis;
Obesity;
Overweight;
Prognosis;
Prostate;
Prostate-Specific Antigen;
Prostatectomy;
Prostatic Neoplasms;
Retrospective Studies;
Survival Rate;
Taxoids
- From:Korean Journal of Urology
2012;53(11):761-765
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated the correlation between body mass index (BMI) and the prognosis of castration-resistant prostate cancer (CRPC) in patients who received docetaxel treatment. MATERIALS AND METHODS: A retrospective study was conducted of 55 patients who were diagnosed with CRPC and received docetaxel treatment between 2003 and 2009 at our institution. Patients with a normal or lower BMI (<23.0 kg/m2) were categorized as group I and patients with an overweight or greater BMI (> or =23.0 kg/m2) were categorized as group II. Clinicopathological features and survival rates were evaluated by using the Kaplan-Meier method and Cox proportional hazards models. RESULTS: On the basis of BMI, 27 patients (49.1%) belonged to group I and 28 (50.9%) patients belonged to group II. Mean follow-up periods were 30 months and 34.2 months, respectively (p=0.381). There were no significant differences between the two groups in terms of age, prostate-specific antigen (PSA), Gleason score, Eastern Cooperative Oncology Group Performance Status, hemoglobin level, alkaline phosphatase level, distant metastasis, radiation treatments, or performance of radical prostatectomy (p>0.05). In the univariate analysis for predicting survival rates, BMI (p=0.005; hazard ratio [HR], 0.121), logPSA (p=0.044; HR, 2.878), and alkaline phosphatase level (p=0.039; HR, 8.582) were significant factors for prediction. In the multivariate analysis, BMI (p=0.005; HR, 0.55), logPSA (p=0.008; HR, 7.836), Gleason score (p=0.018; HR, 6.434), hemoglobin (p=0.006; HR, 0.096), alkaline phosphatase level (p=0.005; HR, 114.1), and metastasis to the internal organs (p=0.028; HR, 5.195) were significant factors for prediction. CONCLUSIONS: Better effects on the cancer-specific survival rate were observed in cases with higher BMI.
