Risk Factors of Nosocomial Bacteremia of Extended-spectrum beta-Lactamase Producing Escherichia coli.
10.12701/yujm.2013.30.2.83
- Author:
Daisik KO
1
;
Song Mi MOON
;
Ji Sung LEE
;
Yoon Soo PARK
;
Yong Kyun CHO
Author Information
1. Gachon University School of Medicine, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Extended-spectrum beta-lactamase;
Escherichia coli;
Nosocomial;
Bacteremia
- MeSH:
APACHE;
Bacteremia*;
beta-Lactamases*;
Case-Control Studies;
Causality;
Cross Infection;
Escherichia coli*;
Escherichia*;
Humans;
Infection Control;
Length of Stay;
Mortality;
Prevalence;
Risk Factors*;
Tertiary Healthcare
- From:Yeungnam University Journal of Medicine
2013;30(2):83-89
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli is increasing rapidly worldwide. Treatment options for ESBL-producing E. coli are limited, and infections caused by this organism are associated with improper antibiotic use, a long hospital stay, and increased mortality. Thus, the assessment and early recognition of the risk factors of nosocomial infections due to ESBL-producing E. coli are important for the infection control and proper treatment. METHODS: A case-control study was performed that included nosocomial episodes of ESBL-producing E. coli bacteremia at a tertiary care hospital from January 2004 to December 2007. For each case patient, three controls were randomly selected and data on predisposing factors were collected. RESULTS: Fifty-five cases of nosocomial ESBL-producing E. coli bacteremia were studied. Carbapenem usage (OR: 11.3, 95% CI: 1.1-115.9, p=0.041), quinolone usage (OR: 4.5, 95% CI: 1.1-18.8, p=0.042), biliary obstructive disease (OR: 11.8, 95% CI: 3.0-46.7, p<0.001) and the APACHE II score (OR: 1.3, 95% CI: 1.2- 1.5, p<0.001) were analyzed as independent risk factors of nosocomial ESBL-producing E. coli bacteremia. CONCLUSION: Our results showed that physicians caring for patients with risk factors of nosocomial bacteremia should consider ESBL-producing E. coli as the causative organisms of the disease.
