The Utility of Basal Serum Luteinizing Hormone Levels for Screening Central Precocious Puberty in Girls.
10.12701/yujm.2013.30.2.90
- Author:
Jung Ki JU
1
;
Hae Lyoung LEE
;
Young Ah LEE
;
Sang Keun CHUNG
;
Min Jung KWAK
Author Information
1. Department of Pediatrics, Good Gang-An Hospital, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Central precocious puberty;
Luteinizing hormone;
Gonadotropin-releasing hormone stimulation test
- MeSH:
Body Weight;
Estradiol;
Female*;
Follicle Stimulating Hormone;
Gonadotropin-Releasing Hormone;
Gonadotropins;
Humans;
Lutein*;
Luteinizing Hormone*;
Mass Screening*;
Puberty, Precocious*;
ROC Curve;
Sexual Development
- From:Yeungnam University Journal of Medicine
2013;30(2):90-94
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study was conducted to examine if basal luteinizing hormone (LH) levels could be useful for screening central precocious puberty (CPP) in girls. METHODS: A total of 90 girls under the age of 8 years were included in this study. They underwent the gonadotropin-releasing hormone (GnRH) stimulation test at Good Gang-An Hospital from March 2008 to December 2012 for evaluation of premature sexual development. Patients were classified into two groups: the pubertal response group of patients who had 5 IU/L peak LH levels in the GnRH stimulation test, and the prepubertal response group of patients who had LH levels <5 IU/L. Chronological and bone ages, height, weight, body mass index, gonadotropin response to GnRH stimulation, and basal levels of LH, follicle-stimulating hormone, and estradiol were studied in both groups. The relationship between basal LH and peak-stimulated LH was evaluated using Spearman's correlation. To determine the optimal cut-off values of basal LH levels for differentiating between two groups, the receiver operating characteristic (ROC) curves were analyzed. RESULTS: When the correlation between basal LH levels and peak LH after GnRH stimulation was analyzed in all subjects (N=90), basal LH levels had a statistically significant positive correlation with peak stimulated LH levels (rs=0.493, p<0.001). The cut-off level of optimal basal LH was 0.1 IU/L, according to the ROC curves. Its sensitivity was 73.3%, and its specificity was 77.8%. CONCLUSION: The study results showed that serum basal LH levels are useful for screening CPP in girls.
