NK/T-cell Lymphoma Involving Multiple Organs in Renal Transplant Recipient.
- Author:
Sang Wook KIM
1
;
Su Ah SUNG
;
Sang Kyung JO
;
Won Yong CHO
;
Hyoung Kyu KIM
;
Nam Hee WON
Author Information
1. Department of Internal Medcine, College of Medicine, Korea University, Seoul, Korea. wonyong@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Posttransplant lymphoproliferative disorder;
NK/T cell lymphoma;
Stomach;
Heart;
Fever
- MeSH:
Adult;
Autopsy;
Biopsy;
Diarrhea;
Fever;
Heart;
Hemorrhage;
Herpesvirus 4, Human;
Humans;
Incidence;
Kidney Transplantation;
Lymph Nodes;
Lymphoma*;
Lymphoproliferative Disorders;
Pancytopenia;
Prognosis;
Stomach;
Transplantation*
- From:Korean Journal of Nephrology
2004;23(2):358-363
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Posttransplant lymphoproliferative disorders (PTLDs) represent a potentially life-threatening complication following renal transplantation. Their incidence is usually low, in the range of 1-2%. The majority of PTLD is B cell origin and strongly associated with Epstein Barr virus (EBV). PTLD of T cell origin is uncommon and has a poor prognosis. We have experienced a case of NK/T cell lymphoma involving stomach, mesenteric lymph nodes, and heart after renal transplantation. The patient was 34 years old man who received renal transplant in 1999. He was admitted with a complaint of fever and pancytopenia for 2 weeks in 2003. Though antibiotic and antifungal treatment, fever and pancytopenia were continued. On the third hospital day, he present waterly diarrhea. We found multiple hemorrhagic erosions in the stomach by gastrofiberscopy and did biopsy there. Gastric mucosal biopsy showed infiltration by atypical cells between the mucosal glands and submucosal layer. The immunophenotype of these tumor cells were CD3+, UCHL+, and CD56+ and all negative for B cell markers. He was dead because of massive gastrointestinal bleeding after endoscopic biopsy of stomach. The autopsy revealed the widespreading of tumor cells involving heart and mesenteric lymph nodes.
