Cardiovascular Diseases after Solid Organ Transplantation.
10.4285/jkstn.2011.25.4.229
- Author:
Jae Joong KIM
1
Author Information
1. Department of Internal Medicine, Asan Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jjkim@amc.seoul.kr
- Publication Type:Review
- Keywords:
Solid organ transplantation;
Cardiovascular diseases;
Risk factors
- MeSH:
Cardiovascular Diseases;
Dyslipidemias;
Graft Survival;
Humans;
Hypertension;
Immunosuppression;
Organ Transplantation;
Rejection (Psychology);
Risk Factors;
Transplants
- From:The Journal of the Korean Society for Transplantation
2011;25(4):229-238
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Despite recent advances in the prolongation of patient and graft survival, transplant patients continue to die prematurely of cardiovascular disease. Cardiovascular disease after solid organ transplantation is a serious complication caused by numerous factors, most shared with the general population and others specific to transplant recipients including immunosuppressive drugs and renal dysfunction. Among traditional risk factors in general population, hypertension, dyslipidemia and diabetes are more common in solid organ transplant recipients. The control of risk factors is more difficult in transplant recipients than in general population. Immunosuppressive drugs are related to hypertension, dyslipidemia and posttransplant DM. Reduction of immunosuppression is helpful to reduce the risk of cardiovascular disease but may increase the risk of rejection and graft loss. mTOR inhibitor has less potential risk to develop cardiovascular disease. Future development of new immunosuppressive drug with less potential risk of CV disease but same efficacy to prevent rejection and graft loss will be a promising goal to prevent CV disease. In conclusion, multidisciplinary approach that emphasizes evidence-based management of traditional risk factors and development of new immunosuppressive drugs are the best approach to reducing the risk of CV disease after solid organ transplantation.
