Antibacterial Activity of Sanguisorba officinalis against Helicobacter pylori.
10.5625/lar.2010.26.3.257
- Author:
Hyun A LEE
1
;
Sunhwa HONG
;
Hong Geun OH
;
Sang Ho PARK
;
Youn Chul KIM
;
Hyun PARK
;
Gil Saeng JEONG
;
Okjin KIM
Author Information
1. Center for Animal Resources Development, Wonkwang University, Iksan, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Sanguisorba officinalis;
Helicobacter pylori;
antibacterial activity;
herb;
therapy
- MeSH:
Animals;
Ethanol;
Gerbillinae;
Helicobacter;
Helicobacter pylori;
Humans;
Mass Screening;
Plants;
Plants, Medicinal;
Sanguisorba;
Stomach Ulcer;
Urease
- From:Laboratory Animal Research
2010;26(3):257-263
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In this study, a medicinal herbal plant, Sanguisorba officinalis, was examined and screened for anti-Helicobacter pylori (H. pylori) activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Sanguisorba officinalis extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Sanguisorba officinalis extract demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Sanguisorba officinalis extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Sanguisorba officinalis extract. It could be a promising candidate herb treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.
