Comparison of Midazolam Alone versus Midazolam Plus Propofol during Endoscopic Submucosal Dissection.
- Author:
Young Shim CHO
1
;
Euikeun SEO
;
Jung Ho HAN
;
Soon Man YOON
;
Hee Bok CHAE
;
Seon Mee PARK
;
Sei Jin YOUN
Author Information
1. Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea. smpark@chungbuk.ac.kr
- Publication Type:Retracted Publication ; Original Article ; Randomized Controlled Trial
- Keywords:
Endoscopic submucosal dissection;
Sedation;
Midazolam;
Propofol
- MeSH:
Humans;
Midazolam;
Propofol;
Vital Signs
- From:Clinical Endoscopy
2011;44(1):22-26
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: For proper sedation during endoscopic submucosal dissection (ESD), propofol has been widely used. This study aimed to compare the levels of sedation and tolerance of patients treated with midazolam (M group) and a combination of midazolam and propofol (MP group) during ESD. METHODS: A total of 44 consecutive patients undergoing ESD were randomly assigned to the two groups. In the M group, 2 mg of midazolam was given repeatedly to maintain after a loading dose of 5 mg. The MP group initially received 5 mg of midazolam and 20 mg of propofol. Then, we increased the dosage of propofol by 20 mg gradually. RESULTS: The average amount of midazolam was 12 mg in the M group. In the M group, 10 patients were given propofol additionally, since they failed to achieve proper sedation. The average amount of propofol was 181 mg in the MP group. Procedure time, vital signs and rates of complications were not significantly different between two groups. Movement of patients and discomfort were lower in the MP group. CONCLUSIONS: During ESD, treatment with propofol and a low dose of midazolam for sedation provides greater satisfaction for endoscopists compared to midazolam alone.
