Calcipotriol ( MC903 ) Ointment in the Treatment of Psoriasis.
- Author:
Jae Hak YOO
;
Woo Seok KOH
;
Jai Il YOUN
- Publication Type:Original Article
- Keywords:
Calcipotriol;
Psoriais
- MeSH:
Calcitriol;
Calcium;
Erythema;
Humans;
Psoriasis*;
Vitamin D;
Vitamins
- From:Korean Journal of Dermatology
1994;32(4):655-661
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Topical vitamine D analogues have been reported to bean effective treatment in patients with psoriasis. Calcipotriol, a new vitamin D analogue, is effect ve and at least 100 times less calcemic than calcitriol. OBJECTIVE: Our purpose was to study the clinical efficacy, safety and tolerability of calcipotriol ointment in the treatment of psoriasis. METHODS: Twenty five patients with chronic poriasis were treated with calcipotriol ointment(50pg/g) twice daily. Efficacy as meaaured by the clinical degree of erythcimor, scale and thickness of the lesions, and safety were assessecl every 2 weeks. RESULTS: The total score of erythema, scale and thickness of the lesions decreased in 6 weeks from 8.52+0.76 to 3.80+1.7 with calcipotriol. Some patients developed mild and transient local side effects. The laboratory tests including serum calcium remained unchanged. CONCLUSION: Topical applicalion of calcipotriol ointment for 6 week was found to bean effective and safe treatment of psoriasis vulgaris.
