Congenital cytomegalovirus infection: three autopsy case reports.
10.3346/jkms.2000.15.3.337
- Author:
Hyang Mi KO
1
;
Kyung Soo KIM
;
Jae Woo PARK
;
Young Jik LEE
;
Min Young LEE
;
Min Cheol LEE
;
Chang Soo PARK
;
Sang Woo JUHNG
;
Chan CHOI
Author Information
1. Department of Pathology, Kwangju Veterans Hospital, Korea.
- Publication Type:Case Report
- Keywords:
Autopsy;
Cytomegalovirus;
Inclusion Bodies;
In situ Hybridzation
- MeSH:
Autopsy;
Case Report;
Cytomegalovirus Infections/virology;
Cytomegalovirus Infections/pathology*;
Cytomegalovirus Infections/congenital*;
Female;
Fetal Diseases;
Human;
Male;
Pregnancy;
Pregnancy Complications, Infectious
- From:Journal of Korean Medical Science
2000;15(3):337-342
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report three autopsy cases of congenital cytomegalovirus (CMV) infection in fetuses with a review of literature. The clinical manifestations in these cases of congenital CMV infection include intrauterine fetal death, hydrops fetalis, and CMV pneumonia associated with cardiovascular defect. The pathological characteristics were as follows: 1) the kidney was the most frequently involved organ, followed by lung and liver, 2) CMV inclusions were found predominantly in epithelial cells and to a lesser degree in endothelial cells, 3) intrahepatic bile duct epithelial cells were frequently involved, and 4) inflammatory reaction around CMV inclusions was not prominent in the early stage of pregnancy. Diagnostic confirmation was obtained by in situ hybridization (ISH) using a biotinylated CMV-DNA probe, which demonstrated intranuclear inclusions and sometimes recognized cells that did not show intranuclear inclusion.
