Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor.
- Author:
Keunhee KANG
1
;
Joo Hee PARK
;
Ja Young RYU
;
Sang Yup LEE
;
Gang Jee KO
;
Young Joo KWON
Author Information
- Publication Type:Case Report
- Keywords: G-CSF; Anaplastic thyroid carcinoma; Paraneoplastic leukocytosis
- MeSH: Cytokines; Granulocyte Colony-Stimulating Factor; Granulocytes; Humans; Length of Stay; Leukocytes; Leukocytosis; Neck; Prognosis; Pyelonephritis; Thyroid Gland; Thyroid Neoplasms
- From:Blood Research 2013;48(1):63-66
- CountryRepublic of Korea
- Language:English
- Abstract: Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis (APN) was diagnosed and treatment for APN was ongoing, but the WBC count steadily increased to 68.8x10(9)/L. She was diagnosed with anaplastic thyroid carcinoma on her neck mass, and the serum concentration of G-CSF was found to be markedly increased at 1,010 pg/mL. In spite of supportive care, the patient's condition rapidly deteriorated and the patient died on day 23 of hospital stay. Leukocytosis without definite evidence of infection could be a paraneoplastic manifestation in patients with malignant tumors, and paraneoplastic leukocytosis may be related to poor prognosis.
