Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome.
10.4168/aair.2014.6.4.316
- Author:
Juan Juan FU
1
;
Vanessa M MCDONALD
;
Peter G GIBSON
;
Jodie L SIMPSON
Author Information
1. Respiratory Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
- Publication Type:Original Article
- Keywords:
Ageing;
C-reactive protein;
interleukin-6;
asthma;
obstructive airway disease;
comorbidity
- MeSH:
Adult*;
Asthma;
C-Reactive Protein;
Cardiovascular Diseases;
Comorbidity;
Humans;
Inflammation*;
Interleukin-6;
Linear Models;
Logistic Models;
Pulmonary Disease, Chronic Obstructive;
Quality of Life;
Spirometry;
Sputum
- From:Allergy, Asthma & Immunology Research
2014;6(4):316-324
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. METHODS: In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. RESULTS: Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. CONCLUSIONS: Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target.
