Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With "Western or Eastern Environments/Lifestyles".
10.4168/aair.2014.6.4.350
- Author:
Guicheng ZHANG
1
;
Siew Kim KHOO
;
J Mika MAKELA
;
Pierre CANDELARIA
;
M Catherine HAYDEN
;
Leena VON HERTZEN
;
Tiina LAATIKAINEN
;
Erkki VARTIAINEN
;
Jack GOLDBLATT
;
Tari HAAHTELA
;
N Peter LESOUEF
Author Information
1. School of Paediatrics and Child Health, University of Western Australia, Australia. Guicheng.zhang@uwa.edu.au
- Publication Type:Original Article
- Keywords:
Allergy;
IgE;
IL-4;
IL-13;
maternal genetic effects
- MeSH:
Alleles;
Child;
Genotype;
Heterozygote;
Homozygote;
Humans;
Hypersensitivity;
Immunoglobulin E*;
Interleukin-13;
Interleukin-4;
Mothers;
Polymorphism, Single Nucleotide
- From:Allergy, Asthma & Immunology Research
2014;6(4):350-356
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated maternal genetic effects of four IL-4/IL-13 pathway genes as well as their interactions with the "Western or Eastern lifestyles/environments" on IgE in Karelian children. METHODS: This study included 609 children and their mothers. Total IgE levels in children and mothers were measured and 10 single nucleotide polymorphisms (SNPs) in IL-4, IL-4Ra, IL-13, and STAT6 were genotyped in mothers and their children. RESULTS: The maternal G allele of IL-13 130 (rs20541) was significantly (P=0.001) associated with decreased IgE in children in the Karelian population (Pooling Finnish and Russian children), as well as in Finnish (P=0.030) and Russian children (P=0.018). The IgE levels were significantly (P=0.001) higher in Russian children whose mothers were homozygous for the G allele of the IL-4Ra 50 (rs1805010) SNP than that in Russian children of mothers who were AG heterozygotes or AA homozygotes. After accounting for children's genotypes, we observed interactive effects on children's IgE for maternal IL-13 130 genotypes (P=0.014) and maternal IL-4Ra 50 genotypes (P=0.0003) with "Western or Eastern" lifestyles/environments. With the adjustment for multiple comparisons using a false discovery rate (FDR) of 0.05, the interactive effect of the maternal IL-4Ra50 SNP was significant. CONCLUSION: Maternal genetic variants in IL-4/IL-13 pathway genes, such as IL-13 130 and IL-4Ra50, influenced IgE levels in school children that were independent of the children's genetic effects. These effects differ in "Western or Eastern" environments.
