Changes in the Levels of Interleukins 6, 8, and 10, Tumor Necrosis Factor Alpha, and Granulocyte-colony Stimulating Factor in Korean Burn Patients: Relation to Burn Size and Postburn Time.
10.3343/alm.2012.32.5.339
- Author:
Hyun Soo KIM
1
;
Jong Hyun KIM
;
Haejun YIM
;
Dohern KIM
Author Information
1. Department of Laboratory Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Burns;
Cytokines;
Body surface area;
Time
- MeSH:
Adolescent;
Adult;
Aged;
Asian Continental Ancestry Group;
Burns/blood/*pathology;
Granulocyte Colony-Stimulating Factor/*blood;
Humans;
Interleukin-10/*blood;
Interleukin-6/*blood;
Interleukin-8/*blood;
Male;
Middle Aged;
Republic of Korea;
Time Factors;
Tumor Necrosis Factor-alpha/*blood;
Young Adult
- From:Annals of Laboratory Medicine
2012;32(5):339-344
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Major burn injury induces an inflammatory response that is accompanied by the release of various cytokines. We investigated the gradual changes in the levels of pro-inflammatory and anti-inflammatory cytokines following burn injury and determined the relationship between these levels and burn size in adult Korean patients with burn injury. METHODS: Blood samples from 9 healthy controls and 60 Korean burn patients were collected on days 1, 3, 7, 14, and 21 after burn injury, and concentrations of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-alpha, and granulocyte-colony stimulating factor (G-CSF) were measured. Burn patients were divided into 3 groups according to burn size (15-30%, 31-50%, >50% total body surface area), and the concentrations of the cytokines were compared between these groups and the control group over 3 weeks. RESULTS: Compared to their levels in controls, IL-6, IL-8, IL-10, TNF-alpha, and G-CSF levels in burn patients were significantly higher during the observation period. Median concentrations of IL-8, IL-10, and G-CSF at each time point increased with burn size, although peak levels and time to peak levels of these cytokines differed from patient to patient. CONCLUSIONS: These findings indicate that IL-6, IL-8, IL-10, TNF-alpha, and G-CSF are important mediators in inflammatory changes after burn injury; however, various factors, including burn size, may influence the concentrations of these cytokines.
