Expression of Tubular Intercellular Adhesion Molecule-1 (ICAM-1) as a Marker of Renal Injury in Children with IgA Nephropathy.
- Author:
Young Ho SON
1
;
Mi Seon KANG
;
Woo Yeong CHUNG
Author Information
1. Departments of Pediatrics, Inje University, College of Medicine, Busan Paik Hospital, Busan, Korea. chungwy@chollian.net
- Publication Type:Original Article
- Keywords:
IgA nephropathy;
Intercellular adhesion molecule-1;
Renal tubule;
Predictive marker;
Children
- MeSH:
Atrophy;
Biopsy;
Child*;
Classification;
Epithelium;
Female;
Fibrosis;
Glomerulonephritis, IGA*;
Hematuria;
Humans;
Immunoglobulin A*;
Intercellular Adhesion Molecule-1*;
Male;
Proteinuria;
Retrospective Studies;
Streptavidin
- From:Journal of the Korean Society of Pediatric Nephrology
2004;8(2):149-158
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In order to evaluate the value of the renal expression of ICAM-1 as a marker of renal injury, we analyzed the relationship between abnormal tubular expression of ICAM-1 and histopathological features and clinical manifestations in children with IgA nephropathy (IgAN). METHODS: The clinical data from 43 patients with IgAN were analyzed retrospectively and compared to the histopathologic subclassification proposed by Haas. ICAM-1 in tubular epithelium was assessed using the LSAB(Labeled streptavidine biotin) kit on the renal biopsy specimens. RESULTS: In 43 patients with primary IgAN, 28 males and 15 females aged 12.2+/-2.2 years were studied. There were no differences of renal tubular expression of ICAM-1 between patients with gross hematuria and without gross hematuria. But renal tubular expression of ICAM-1 in patients with proteinuria was significantly higher than that of in patients without proteinuria(78.72+/-14.19% vs. 55.80+/-32.20%, P<0.05). Renal tubular expression of ICAM-1 was also associated with the severity of histopathological degree using Haas classification method. In subclass I, renal tubular expression of ICAM-1 was significantly lower than those of other subclasses. A significant correlation was found between the tubular expression of ICAM-1 and the total amount of protein in 24 hour collected urine(rs=0.47236, P<0.05). But there were no significant correlations between the renal tubular expression of ICAM-1 and interstitial cellular infiltration, tubular atrophy, and interstitial fibrosis respectively(F=0.89, P>0.05; F=0.31, P>0.05; F=0.21, P>0.05). CONCLUSION: Renal tubular expression of ICAM-1 can be a useful marker of renal injury in children with IgAN.
