The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study.
- Author:
Su Jin HONG
1
;
Soo Heon PARK
;
Jeong Seop MOON
;
Woon Geon SHIN
;
Jae Gyu KIM
;
Yong Chan LEE
;
Dong Ho LEE
;
Jae Young JANG
;
Jae J KIM
;
Hang Lak LEE
;
Sang Woo LEE
;
Young HWANGBO
;
Jianming XU
;
Bangmao WANG
;
Zhanxiong XUE
;
Fei LIU
;
Yaozong YUAN
;
Somchai LEELAKUSOLVONG
;
Frederick DY
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Peptic esophagitis; Symptoms; Heartburn; Rebamipide; Esomeprazole
- MeSH: Esomeprazole*; Esophagitis, Peptic*; Heartburn; Humans
- From:Gut and Liver 2016;10(6):910-916
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. METHODS: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. RESULTS: The mean decreases in the total symptom score at 4 weeks were estimated to be −18.1±13.8 in the combination therapy group and −15.1±11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were −8.4±6.6 in the combination therapy group and −6.8±5.9 in the monotherapy group (p=0.009). CONCLUSIONS: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.
