The Relationship Between Increased Intracranial Pressure and Central alpha-Adrenoceptors.
- Author:
Sung Sin DOH
1
;
Hyoung Kun KIM
;
Kwang Yong CHO
Author Information
1. Department of Neurosurgery, Chosun University, School of Medicine, Gwangju, Korea.
- Publication Type:Original Article
- Keywords:
Balloon method;
B-HT 920;
Piperoxan;
Prazosin;
alpha2-adrenoceptor
- MeSH:
Blood Pressure;
Inflation, Economic;
Intracranial Pressure*;
Piperoxan;
Prazosin;
Rabbits
- From:Journal of Korean Neurosurgical Society
1983;12(1):71-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The author attempted to clarify the nature of alpha-adrenoceptors in relation to the pressor response to the increased intracranial pressure(ICP) in urethane-anesthetized rabbits, using the epidural balloon method. 1) The blood pressure increased in parallel with the raised ICP which was made by gradual inflation of the balloon. 2) B-HT 920, an alpha2-agonist, which elicited depressor and bradycardiac responses in normal rabbits inhibited markedly the pressor response to the raised ICP. 3) Piperoxan, an alpha2-antagonist, potentiated the pressor response to the raised ICP. 4) Piperoxan antagonized the depressor and bradycardiac responses by B-HT 920 as well as the inhibitory effect of B-HT 920 on the pressor response to the raised ICP. 5) The pressor response to the raised ICP were not affected at all by prazosin, an alpha1-antagonist. 6) Neither the depressor and bradycardiac responses by B-HT 920 itself nor the inhibitory effect of B-HT 920 on the pressor response to the raised ICP were significantly affected by prazosin. It is inferred from these observations that the central alpha-adrenoceptors play an important role in producing the pressor response to the raised ICP and that the receptors involved here seems to be of alpha2-type.
