Two Cases of Nontuberculous Mycobacterial Lung Disease in Heart Transplant Recipients.
10.4046/trd.2010.69.3.201
- Author:
Jung Min JO
1
;
Mi Seon SHIN
;
Joo Hui KIM
;
Min Jung KIM
;
Hyun Jung PARK
;
Hee Kyung NA
;
Kyung Uk JO
;
Jae Joong KIM
;
Tae Sun SHIM
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Mycobacteria, Atypical;
Heart Transplantation;
Lung Diseases
- MeSH:
Adult;
Amikacin;
Bronchiectasis;
Ciprofloxacin;
Clarithromycin;
Cough;
Ethambutol;
Female;
Heart;
Heart Transplantation;
Humans;
Imipenem;
Lung;
Lung Diseases;
Middle Aged;
Nontuberculous Mycobacteria;
Opportunistic Infections;
Sputum;
Thorax;
Transplants
- From:Tuberculosis and Respiratory Diseases
2010;69(3):201-206
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nontuberculous mycobacterial (NTM) diseases are increasing worldwide. However NTM lung disease in organ transplant recipients has been rarely reported. Here, we report 2 cases of NTM lung disease in heart transplant recipients. A 37-year-old man, who had undergone a heart transplant one year previous, was admitted to hospital due to a cough. Chest CT scan showed multiple centrilobular nodules in both lower lungs. In his sputum, M. abscessus was repeatedly identified by rpoB gene analysis. The patient improved after treatment with clarithromycin, imipenem, and amikacin. An additional patient, a 53-year-old woman who had undergone a heart transplant 4 years prior and who suffered from bronchiectasis, was admitted because of purulent sputum. The patient's chest CT scan revealed aggravated bronchiectasis; M. intracellulare was isolated repeatedly in her sputum. Treatment was successfully completed with clarithromycin, ethambutol, and ciprofloxacin. NTM lung disease should be considered as a potential opportunistic infection in organ transplant recipients.
