Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Tissue Type Involving the Dura.
- Author:
Joon Young CHOI
1
;
Ji Hwan CHUNG
;
Young Jun PARK
;
Geun Yong JUNG
;
Tae Wook YOON
;
Yoon Jung KIM
;
Tae kyu LIM
;
Bong Seog KIM
;
Seung Hyun NAM
Author Information
- Publication Type:Case Report
- Keywords: Dura mater; Marginal zone B-cell lymphoma; Central nervous system neoplasms
- MeSH: Aged; B-Lymphocytes; Brain; Central Nervous System; Central Nervous System Neoplasms; Diagnosis, Differential; Drug Therapy; Dura Mater; Headache; Humans; Lymphoid Tissue; Lymphoma, B-Cell, Marginal Zone*; Magnetic Resonance Imaging; Meningioma; Phenotype
- From:Cancer Research and Treatment 2016;48(2):859-863
- CountryRepublic of Korea
- Language:English
- Abstract: Primary central nervous system marginal zone B-cell lymphoma (MZBCL) is very rare, with only a few reported cases worldwide. It has an indolent disease course with high cure potential. We experienced a rare case of dural MZBCL of mucosa-associated lymphoid tissue (MALT) in a 69-year-old man who presented with headache. A magnetic resonance imaging scan of brain showed a 1.9×3.6-cm-sized extra-axial mass with a broad based dural attachment to the anterosuperior aspect of the falx cerebri, radiographically consistent with meningioma. Surgical resection yielded a MZBCL of the MALT type. Histopathology revealed a lymphoplasmacytic infiltration of the dura, and immunohistochemical study showed a B-cell phenotype with CD20, bcl-2, MUM-1, Ki-67 positive. He was treated with chemotherapy after complete surgical resection and remained free of disease at 30 months after chemotherapy. MALT lymphoma must be considered in the differential diagnosis in patients presenting radiographically with meningioma.
