Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma.
- Author:
Min Ho LEE
1
;
Ju Hee LEE
;
Ho Jun SEOL
;
Jung Il LEE
;
Jong Hyun KIM
;
Doo Sik KONG
;
Do Hyun NAM
Author Information
- Publication Type:Original Article
- Keywords: Nonfunctioning; Pituitary adenoma; Radiotherapy; Recurrence; Radiosurgery
- MeSH: Electronic Health Records; Female; Follow-Up Studies; Humans; Hypopituitarism; Immunohistochemistry; Male; Pituitary Neoplasms*; Radiosurgery; Radiotherapy; Radiotherapy, Adjuvant; Recurrence*; Retrospective Studies; Surgical Equipment
- From:Brain Tumor Research and Treatment 2016;4(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Non-functioning pituitary adenomas (NFPA) are clinically challenging because they present at a late stage with local mass effects or hypopituitarism. Surgery for non-functioning pituitary adenoma requires a special strategic approach for both minimal morbidity and radical resection. However, the clinical predictive factors associated with recurrence are limited. Here, we investigated optimal treatment of non-functioning pituitary adenoma. METHODS: We enrolled 289 patients who presented with non-functioning pituitary adenoma between January 2000 and January 2012 and who had received follow-up for at least one year for this retrospective study. Of these patients, 152 were male and 137 were female, with a median age of 51 years (range 15.79 years) and a median follow-up of four years (range 1.12.6 years). Characteristics of patients and tumors were reviewed with electronic medical records and radiologic images, retrospectively. RESULTS: Of the tumors, 193 were gross-totally resected, 53 were near-totally resected, and 43 were sub-totally resected. The extent of resection and adjuvant radiotherapy were both statistically significant prognostic factors of recurrence. Immunohistochemistry of tumor specimens did not yield consistent results. CONCLUSION: With a high rate of recurrence, NFPA should be closely followed-up over a long-term period. Improvement of surgical techniques with advanced surgical equipment and adjuvant radiosurgery would lead to reduce the recurrence rate and improve patients' outcome.
