A Case of Toxic Epidermal Necrolysis Treated with High Dose Intravenous Immunoglobulin.
- Author:
Man Heui HAN
1
;
Sook Kyung KANG
;
Kyung Jeh SUNG
;
Kee Chan MOON
;
Jai Kyoung KOH
;
Jee Ho CHOI
Author Information
1. Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Toxic epidermal necrolysis;
Intravenous immunoglobulin
- MeSH:
Adult;
Antigens, CD95;
Apoptosis;
Cell Death;
Epidermis;
Female;
Humans;
Immunoglobulins*;
Immunoglobulins, Intravenous;
Iritis;
Necrosis;
Prednisolone;
Skin;
Stevens-Johnson Syndrome*
- From:Korean Journal of Dermatology
2000;38(7):940-944
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Toxic epidermal necrolysis(TEN) is the most dramatic, life-threatening cutaneous drug reaction. TEN is characterized by extensive detachment of the epidermis undergoing full-thickness necrosis. The pathogenetic pathway and specific treatments of TEN have not yet been identified. Recently, several reports suggested that apoptosis in TEN is promoted by proteins such as Fas antigen and high dose intravenous immunoglobulin(IVIG) inhibits Fas-mediated cell death by blocking the Fas receptor. We report a case of TEN in a 26-year-old woman who had been treated with prednisolone due to iritis. She was treated with high dose IVIG(0.4g/Kg/day for 4 days one day and 0.7g/Kg/day for consecutive). In our case, the progression of skin lesion was interrupted after IVIG infusion and favorable vital outcome was achieved with mild adverse effects.
