Association Study of the Relationship between Endometriosis and Polymorphism of p53 Codon 72.
- Author:
Sung Eun HUR
1
;
Soung Shin SHIM
;
Kyung Soon LEE
;
Hye Sung MOON
;
Han Ki YU
;
Hye Won CHUNG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University. Korea. hyewon@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Endometriosis;
p53;
Polymorphism;
Arginine;
Proline
- MeSH:
Arginine;
Codon*;
Endometriosis*;
Female;
Heterozygote;
Homozygote;
Humans;
Polymerase Chain Reaction;
Proline
- From:Korean Journal of Fertility and Sterility
2002;29(4):311-316
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The present study was performed to evaluate the association of p53 codon 72 polymorphism and endometriosis. MATERIALS AND METHODS: We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis. CONCLUSION: Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.
