A Case of the Milk-alkali Syndrome During Management of Idiopathic Hypoparathyroidism.
- Author:
Yong Wan PARK
1
;
Sung Rae KIM
;
Jung Min LEE
;
Seong Hun KIM
;
Sang Woo HAN
;
Soon Jib YOO
;
Kun Ho YOON
;
Moo Il KANG
;
Bong Yun CHA
;
Kwang Woo LEE
;
Ho Young SON
;
Sung Koo KANG
Author Information
1. Department of internal medicine, Catholic university, College of medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Milk-alkali syndrome;
Idiopathic hypoparathyroidism
- MeSH:
Alkalosis;
Calcium;
Calcium Carbonate;
Diuresis;
Eating;
Furosemide;
Humans;
Hypercalcemia*;
Hypercalciuria;
Hyperphosphatemia;
Hypocalcemia;
Hypoparathyroidism*;
Metabolism;
Parathyroid Hormone;
Rare Diseases;
Renal Insufficiency;
Vitamin D
- From:Journal of Korean Society of Endocrinology
2004;19(4):439-445
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Idiopathic hypoparathyroidism is a relatively rare disease characterized by hypocalcemia and hyperphosphatemia: this is due to a deficiency or a sereretory disorder of the parathyroid hormone without any prior operation nor underlying medical disoder. Calcium carbonate and vitamin D substitution are generally considered as the mainstay of therapy, but these treatments can cause hypercalcemia and hypercalciuria. Persistent ingestion of large amount of calcium carbonate can cause milk-alkali syndrome that is characterized by hypercalcemia, metabolic alkalosis and renal failure. Once a patient is diagnosed with milk-alkali syndrome, withdrawal of calcium carbonate and vitamin D is essential and treatment with saline diuresis and furosemide is the usually effective. In treatmenf of hypoparathyroidism with calcium carbonate and vitamin D substitution, evaluation of serum calcium and urinary calcium excretion is essential to avoid hypercalcemia and ypercalciuria. We concluded that during treatment with calcium carbonate and vitamin D substitution for patients with idiopathic hypoparathyroidism, they should have carefully laboratory monitoring, and they should be made aware of the circumstances influencing calcium metabolism
