Antiangiogenic Effects of Retinoids on Corneal Neovascularization.
- Author:
Yong Suk CHOI
1
;
Young Suk YU
;
Jag Jun LEE
;
Hum CHUNG
;
Jaeheung LEE
;
Hong Leen CHANG
Author Information
1. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Antiangiogenic effect;
Chemical cauterization;
Computerized image analyzer;
Corneal neovascularization;
Retinoids
- MeSH:
Animals;
Blood Vessels;
Cautery;
Cornea;
Corneal Neovascularization*;
Dimethyl Sulfoxide;
Gelatin;
India;
Ophthalmic Solutions;
Rats;
Rats, Wistar;
Retinaldehyde;
Retinoids*;
Tretinoin
- From:Journal of the Korean Ophthalmological Society
1996;37(9):1413-1421
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We investigated the effect of topical application of retimids on the corneal neovascularization in the rat induced by chemical cauterization. The center of corneas of Wistar rats were Cauterized with a silver/potassium nitrate applicator for 5 seconds. And then they were treated topically with 0.1%, 0.2%, 0.5%, 2.0% all-trans retimids (retinol, retinoic acid, retinaldehyde) and dimethyl sulfoxide as a control four times a day. After appiications of eye drops for 5 days, each rat was kined and then perfused with a mixture of 11% gelatin 10% India ink-lactated Ringer's solution. Corneal flat preparation were made, and then the percent of the corneal area occupied by blood vessels were analized by computerized image analyzer. Percent vascularization of 0.1% and 0.2% retnoids were not significantly different from control group(p>0.05). Percent vascu1arization of 0.5% retinaldehyde and all 2.0% retnoids were significantly lower than the contml group(p>0.5). These naturally occurring retinoids were effective in antiarlgiogenesis of rat cornea at relatively high concentrations (>0.5%), when treated topicany, It will be necessary to further study on more potent antiangiogenic, at lower concentration, synthetic retimids for the treatment of angiogenic diseases.
