The Plasma Level of Matrix Metalloproteinase (MMP)-2, -9 between Antepartum and Postpartum Period in Preeclampsia.
- Author:
Hye Jin CHANG
1
;
Jeong In YANG
;
Ho Bin KIM
;
Hang Soo KIM
;
Hee Sug RYU
;
Ki Suk OH
Author Information
1. Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Original Article
- Keywords:
Preeclampsia;
Matrix metalloproteinase-2;
Matrix metalloproteinase-9
- MeSH:
Female;
Gestational Age;
Humans;
Immunoassay;
Maternal Age;
Matrix Metalloproteinase 2;
Matrix Metalloproteinase 9;
Parity;
Plasma*;
Postpartum Period*;
Pre-Eclampsia*;
Pregnant Women
- From:Korean Journal of Obstetrics and Gynecology
2004;47(8):1487-1491
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the changes of plasma MMP-2, -9 levels in preeclampsia between antepartum and postpartum periods, and compare with normotensive pregnant. METHODS: Plasma MMP-2, -9 levels were determined with enzyme-linked immunoassay in pregnant women with preeclampsia (n=20) compared to control group (normotensive pregnant women) matched by maternal age, gestational age, and parity (n=20). RESULTS: Women with preeclampsia presented significantly higher plasma level of MMP-2 before delivery [516.33 +/- 98.75 vs 384.55 +/- 93.84 (ng/mL), p=0.002]. In postpartum 24 hours, women with preeclampsia exhibited higher plasma MMP-2 level compared control group [534.77 +/- 158.67 vs 336.04 +/- 139.11 (ng/mL), p=0.002]. But the plasma level of MMP-9 was significantly lower in preeclampsia group before delivery [26.26 +/- 7.49 vs 45.00 +/- 20.31 (ng/mL), p=0.001]. In postpartum 24 hours, women with preeclampsia also speculated lower plasma MMP-9 level compared control group, but no existence of significance. CONCLUSION: Plasma MMP-2 concentration is significantly increased in preeclampsia before delivey and postpartum 24 hours. Plasma MMP-9 concentration is significantly decreased in preeclampsia before delivery.
